Force Enhancement of Musculus Quadriceps Femoris During and After Excentric Muscle Activity in Vivo

• Conditions: Muscle Quadriceps Femoris; Healthy
• Interventions: Other: muscle activation

• Registration Number: NCT00690547
• Lead Sponsor: German Research Foundation

Brief Summary

Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. In vitro trials indicate that the interaction of an active and a passive component on the cellular level are responsible for the higher strength measurements. So far FE could be shown in vitro and in vivo on muscle fibers and small human muscles. Further research is needed for verification of the existence of FE in voluntary motor activity in everyday life. In order to approach this objective the investigators will scrutinize the functionality of the deliberately activated musculus (m) quadriceps femoris during and after active extension on the basis of in vivo studies.

Detailed Description

The research proposal is resubmitted with no amendments made regarding content.

Study Timeline

• Study First Submitted: 2008-05-30
• Study First Submitted QC: 2008-06-03
• Study First Posted: 2008-06-04
• Study Start: 2008-10
• Status Verified: 2009-11
• Last Update Submitted: 2009-11-27
• Last Update Posted: 2009-11-30
• Primary Completion: 2010-10
• Study Completion: 2010-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Males without previous muscular or neurophysiological diseases
• Age between 20 and 40 years

Exclusion Criteria

• Previous muscular or neurophysiological diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Test Group	muscle activation	-

Primary Outcome Measures

Name	Time	Method
Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend).	12 months

Secondary Outcome Measures

Name	Time	Method
Evidence of existence of the force enhancement by deliberately activated, great human muscle by sub-maximal activation	12 months
Correlation between typ of muscle fiber and force enhancement in vivo	12 months
Analysis of the alternation of length of the muscle fiber during and after excentric extension for the differentiated explanation of in vivo mechanism excentric and post-excentric strength	12 months

Trial Locations

Locations (1)

Technical University of Munich, Department of Biomechanics in Sports; 🇩🇪 Munich, Germany