Epidemiological, Clinical and Histopathological prognostic factors in Advanced Oral Squamous Cell Carcinoma treated with Surgery followed by Radiotherapy: A Retrospective Observational study

Recruiting

• Conditions: PATIENTS OF ADVANCED ORAL SQUAMOUS CELL CARCINOMA

• Registration Number: CTRI/2013/07/003855
• Lead Sponsor: MAX SUPERSPECIALTY HOSPITAL

Brief Summary

**The primary purpose for conducting this study is to evaluate the effect of various prognostic factors on the treatment response (surgery, radiotherapy and chemotherapy), recurrence status, survival duration and loco regional control in advanced oral squamous cell carcinoma patients.**

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06-02
• Last Update Posted: 2013-07-24

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients of any age.
• Sex: both males and females .
• Histological biopsy confirming Squamous Cell Carcinoma of the Oral cavity (tongue, gingiva, buccal mucosa, floor of mouth, palate, and retro molar region) .
• Clinical stage III/IVA (T1-2, N1-2, M0 or T3-4, N0-2, M0, AJCC 2006) with resectable lesions.
• • Adequate hematologic function: white blood cell >3,000/mm3, hemoglobin>8g/L, platelet count>80,000/mm3.

Exclusion Criteria

• Patients with distant metastatic disease and other cancers • Previous radiotherapy, surgery or chemotherapy done other than Max • Other previous malignancies within last 5 years • Another histological type of tumour or a tumour not involving the oral cavity, • Recurrent tumour after previous treatment.
• • Patients with inadequate follow-up • Patients who have undergone for initial RT.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
•To determine the stage and size of the tumor	from Feb 2009 to Sep 2012
•To determine the regional node size site and number of lymph nodes invaded lymph node sectors invaded presence of extracapsular extention and distant metastasis	from Feb 2009 to Sep 2012
•To assess the kind of the surgical technique and the technique of the radiation used	from Feb 2009 to Sep 2012
•To determine the tumor histology grade depth of invasion presence of LVI and PNI bone invasion tumour differentiation types of surgical margins on the specimen and resection margin	from Feb 2009 to Sep 2012

Secondary Outcome Measures

Name	Time	Method
•To evaluate the early effect of age gender tobacco chewing smoking alcohol consumption dental hygiene and presence of the comorbidities on the prognosis of the disease	from Feb 2009 to Sep 2012

Trial Locations

Locations (1)

MAX SUPERSPECIALTY HOSPITAL; 🇮🇳 Delhi, DELHI, India

MAX SUPERSPECIALTY HOSPITAL

🇮🇳Delhi, DELHI, India

DR HARIT CHATURVEDI

Principal investigator

9810008781

harit.chaturvedi@maxhealthcare.com