Epidemiological, Clinical and Histopathological prognostic factors in Advanced Oral Squamous Cell Carcinoma treated with Surgery followed by Radiotherapy: A Retrospective Observational study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- •To determine the stage and size of the tumor
研究概览
简要总结
The primary purpose for conducting this study is to evaluate the effect of various prognostic factors on the treatment response (surgery, radiotherapy and chemotherapy), recurrence status, survival duration and loco regional control in advanced oral squamous cell carcinoma patients.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 15.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of any age.
- •Sex: both males and females .
- •Histological biopsy confirming Squamous Cell Carcinoma of the Oral cavity (tongue, gingiva, buccal mucosa, floor of mouth, palate, and retro molar region) .
- •Clinical stage III/IVA (T1-2, N1-2, M0 or T3-4, N0-2, M0, AJCC 2006) with resectable lesions.
- •â€¢ Adequate hematologic function: white blood cell >3,000/mm3, hemoglobin>8g/L, platelet count>80,000/mm3.
排除标准
- •Patients with distant metastatic disease and other cancers • Previous radiotherapy, surgery or chemotherapy done other than Max • Other previous malignancies within last 5 years • Another histological type of tumour or a tumour not involving the oral cavity, • Recurrent tumour after previous treatment.
- •â€¢ Patients with inadequate follow-up • Patients who have undergone for initial RT.
结局指标
主要结局
•To determine the stage and size of the tumor
时间窗: from Feb 2009 to Sep 2012
•To determine the regional node size site and number of lymph nodes invaded lymph node sectors invaded presence of extracapsular extention and distant metastasis
时间窗: from Feb 2009 to Sep 2012
•To assess the kind of the surgical technique and the technique of the radiation used
时间窗: from Feb 2009 to Sep 2012
•To determine the tumor histology grade depth of invasion presence of LVI and PNI bone invasion tumour differentiation types of surgical margins on the specimen and resection margin
时间窗: from Feb 2009 to Sep 2012
次要结局
- •To evaluate the early effect of age gender tobacco chewing smoking alcohol consumption dental hygiene and presence of the comorbidities on the prognosis of the disease(from Feb 2009 to Sep 2012)