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临床试验/NCT05392816
NCT05392816已完成不适用

Non-heme Iron Absorption From Single Meals of Fava Bean Protein, Beef Protein and Cod Protein in Healthy Females in Fertile Ages

Chalmers University of Technology2 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2021年9月6日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
30
试验地点
2
主要终点
59Fe non-heme iron absorption from cod and beef protein meals

研究概览

简要总结

The aim of this study is to investigate the non-heme iron absorption from single meals of texturized fava bean protein, which has been suggested as a protein source suitable for replacement of meat, compared to the non-heme iron absorption from beef protein and cod protein meals. The study participants are women of fertile ages, which is one of the main groups at risk of developing iron deficiency. Since a dietary shift towards increasingly plant based is being pushed, investigating nutritional effects of such a shift is essential to avoid potential negative effects such as an increase of nutritional deficiencies. The study includes two cross-over single-blinded iron isotope trials in apparent healthy Swedish women of the ages 18-45 years, each of whom served as their own control. Participants will be served matched test meals containing beef and fava bean protein (Study 1), or cod and fava bean protein (Study 2) with radiolabeled non-heme iron 55Fe and 59Fe. Absorption of non-heme iron from test meals will be measured by whole-body counting, and erythrocyte incorporation by liquid scintillation.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Other
盲法
Single (Participant)

盲法说明

Meals are served from identical plastic boxes. Participants are served the meals in a separate room from preparation

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Age 18-45
  • Is tolerant to intake of fava bean
  • Eats fish and meat
  • Feels healthy
  • Can eat a breakfast consisting of three potato-based patties

排除标准

  • Other sex than female
  • Age <18 and >45
  • Has an ongoing infection
  • Is vegetarian
  • Is pregnant or lactating
  • Takes iron supplements

结局指标

主要结局

59Fe non-heme iron absorption from cod and beef protein meals

时间窗: 5 weeks

Absorption of 59Fe, which is added to the animal protein meals, will be measured by a whole body counter which enables measurement of absolute value.

55Fe non-heme iron absorption from fava bean protein meals.

时间窗: 5 weeks

The absorption quota of 59Fe/55Fe is measured by erythrocyte incorporation, analyzed by liquid scintillation. The absorbance quota, in combination with the absolute value of the whole body counter, will be used to calculate the absorbance of 55Fe which is added to the fava bean meals

次要结局

未报告次要终点

研究者

发起方
Chalmers University of Technology
申办方类型
Other
责任方
Principal Investigator
主要研究者

Rikard Landberg

Professor

Chalmers University of Technology

研究点 (2)

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