The effect of insulin detemir on energy balance, postprandial nutrient handling, body fat distribution and adipose tissue metabolism and gene expression in patients with type 2 diabetes

Not Applicable

Completed

• Conditions: Topic: Diabetes Research Network; Subtopic: Type 2; Disease: Insulin switch, Metabolic; Nutritional, Metabolic, Endocrine; Type 2 diabetes

• Registration Number: ISRCTN72730583
• Lead Sponsor: niversity of Surrey (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2009-10-01
• Study Start: 2010-07-30
• Last Update Posted: 4 May 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

1. Type 2 diabetes
2. Treated with metformin
3. Already on treatment with a long-acting or intermediate insulin
4. Aged greater than or equal to 18 years of age, either sex
5. HbA1c greater than 7.0%
6. Body mass index (BMI) 27 - 40 kg/m^2
7. Able and willing to perform self-blood glucose monitoring
8. Able and willing to maintain consistent eating habits throughout the entire trial period
9. Able and willing to maintain consistent physical activity level during the entire trial period

Exclusion Criteria

1. Patients on sulphonylureas or thiazolidinediones
2. Proliferative retinopathy that has required acute treatment within the last six months
3. Impaired hepatic or renal functions
4. Cardiac problems
5. Uncontrolled hypertension (treated or untreated)
6. Mental incapacity, unwillingness or a language barrier precluding adequate understanding or co-operation

Study & Design

• Study Type: Interventional
• Study Design: Not specified