Role of Nutritionist in the Multidisciplinary Approach of Hidradenitis Suppurativa (Acne Inversa)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 81
- 主要终点
- Trimethylamine N-oxide plasma levels
研究概览
简要总结
Hidradenitis suppurativa (HS) is a chronic inflammatory, debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity. The objective of this study was to investigate the relationships between body composition and the adherence to the Mediterranean diet (MD) with the severity of HS in a sample of naïve-treatment patients with HS. In the wake of this evidence, in the study to investigate the relationships between nutritional status, the adherence to the MD, body composition, and the severity of HS in a sample of naïve-treatment patients with HS compared to control group matched for sex, age, and body weight.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy subjects of both gender
- •treatment-naïve patients
- •had HS diagnosed ≥6 months before study initiation wash out therapy for at least 3 months
排除标准
- •occasional or current of use of drugs for HS, including topical antibiotics and systemic treatments (such as clindamycin-rifampicin, tetracycline, Rifampicin-moxifloxacin-metronidazole, ertapenem, acitretin, cyclosporine A, dapsone, isotretinoin, biologics;
- •hypocaloric diet in the last three months or specific nutritional regimens;
- •vitamin/mineral or antioxidant supplementation;
- •occasional or current of use of drugs that could influence fluid balance, including non-steroidal anti-inflammatory drugs, hormone replacement therapy.
结局指标
主要结局
Trimethylamine N-oxide plasma levels
时间窗: April 2015 to April 2018
ultra high-performance liquid chromatography
Adherence to Mediterranean Diet by Predimed Questionnaire
时间窗: April 2015 to April 2018
Validated 14-item tool of adherence to the Mediterranean diet, with three categories of adherence (≤5, low adherence, 6-9, average adherence and ≥10 points, high adherence)
Phase angle
时间窗: April 2015 to April 2018
Phase angle was performed using a BIA phase-sensitive system by experienced observers (an 800-µA current at a frequency single-frequency of 50 kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy).
次要结局
- Vitamin D(April 2015 to April 2018)
研究者
Prof. Silvia Savastano
Associate Professor
Federico II University