NL-OMON49236已完成不适用
Exposure to orally administered antibiotics during the initial phase of infection in non-critically ill, febrile patients - EXPO-AB
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age *18 years
- •Acute febrile illness, defined as a temperature *38.3 and in need of IV
- •antibiotic therapy for an infection for which amoxicillin or ciprofloxacin are
- •registered treatments
- •Able to take oral medication, that is no abdominal pathology or history of
- •abdominal pathology that may alter absorption (i.e. vomiting, mucositis,
- •diarrhoea, malabsorption syndrome, former abdominal surgery affecting
- •absorption)
- •Able and willing to give informed consent
排除标准
- •Critically ill patients, admitted to the ICU, or infectious patients of the
- •general ward who became critically ill and got transferred to the ICU during
- •the research period.
- •Comorbidity affecting absorption: hepatic impairment, i.e. active hepatitis,
- •hepatic failure, liver cirrhosis or severe renal impairment (GFR <30),
- •Neutropenic patients (neutrophil count <1000/µl) and patients treated with
- •chemotherapy within 28 days prior to the study.
- •Contraindications to use ciprofloxacin or amoxicillin
- •o Ciprofloxacin: allergy to fluoroquinolones, concomitant administration of
- •o Amoxicillin: allergy to penicillins or proven allergy to another beta-lactam
- •agent (e.g. cephalosporin, carbapenem or monobactam).
- •Penicillin/fluoroquinolone treatment during the week prior to study enrolment
- •History of alcohol and drug abuse.
研究者
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