Towards a non-invasive anatomical and functional diagnostic work-up of patients with suspected coronary artery disease using Cardiovascular Magnetic Resonance Imaging and Multidetector CT
- Conditions
- coronary artery disease10011082
- Registration Number
- NL-OMON30468
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 220
Inclusion Criteria
VUMC CMR/MDCT work-up because of suspected coronary artery disease (CAD).
Chest pain of intermediate likelihood for significant CAD as determined from age, gender and history (10-90% according to combined Diamond/Forrester/CASS scale; ref: Gibbons RJ et al. Circ 2003;107:149-158.).
No prior documented CAD.
Exclusion Criteria
Any change in clinical condition between the examinations, failure to sign the informed consent.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Diagnostic accuracy of CMR, MDCT calcium score and MDCT coronary angiography<br /><br>for the detection of significant CAD, using invasive coronary angiography as<br /><br>reference standard.<br /><br>Development of a diagnostic algorithm (decision tree model) involving the<br /><br>sequential use of both imaging modalities.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Costs relative to diagnostic accuracy for CMR and MDCT, and for the proposed<br /><br>algorithm.<br /><br>One-year clinical outcome.</p><br>