Zinc Absorption From Zinc Citrate, Zinc Gluconate and Zinc Oxide

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Zinc oxide; Dietary Supplement: zinc citrate; Dietary Supplement: Zinc Gluconate

• Registration Number: NCT01576627
• Lead Sponsor: Prof. Michael B. Zimmermann

Brief Summary

The goal of this trial is to evaluate zinc citrate, a zinc compound with promising sensory properties and a high zinc content, as an alternative zinc compound to be used for supplementation or food fortification. The bioavailability of zinc citrate given as a supplement to young Swiss adults will be assessed and compared to the bioavailability of the commonly used zinc compounds zinc gluconate and zinc oxide.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2012-04-04
• Study First Submitted QC: 2012-04-11
• Study First Posted: 2012-04-12
• Primary Completion: 2012-05
• Study Completion: 2012-11
• Status Verified: 2013-01
• Last Update Submitted: 2013-01-03
• Last Update Posted: 2013-01-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Male or female of 18 to 45 years old
• Body Mass Index in the range of 19 to 25
• No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study

Exclusion Criteria

• Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
• Long-term medication during the whole study (except for contraceptives)
• Vegans
• Pregnancy
• Lactation
• Intention to become pregnant during the course of the study
• Lack of safe contraception
• Consumption of mineral and vitamin supplements within 2 weeks prior to 1st test supplement administration
• Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
zinc oxide	Zinc oxide	-
zinc citrate	zinc citrate	-
zinc gluconate	Zinc Gluconate	-

Primary Outcome Measures

Name	Time	Method
Fractional absorption of zinc	61 days	Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.

Trial Locations

Locations (1)

ETH Zurich; 🇨🇭 Zurich, Switzerland