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临床试验/NCT07358598
NCT07358598尚未招募不适用

The Relationship Between Eye Movement Parameters and Cognitive Functions in Older Adults

National Sun Yat-sen University1 个研究点 分布在 1 个国家目标入组 210 人开始时间: 2026年1月17日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
210
试验地点
1
主要终点
Eye-tracking measurement

研究概览

简要总结

Dementia most commonly occurs in elderly individuals, but currently there is still a lack of objective measurement methods that can detect cognitive impairment in older adults at an early stage. Eye movement is considered a clinical indicator with potential for screening mild cognitive dysfunction, and eye movement signals can be extracted to objectively evaluate cognition. Eye tracking has been used mostly to evaluate patients with neurodegenerative diseases such as Parkinson's disease. However, less attention has been paid to the relationship between eye movement and cognitive function in elderly individuals, as well as the association between eye movement data and abnormal cognitive subdomains. This cross-sectional study will recruit 0204 elderly individuals over the age of 65, divided into three groups (healthy group/mild cognitive impairment group/dementia group) according to the purpose of this study. Participants who have not been diagnosed with neurological diseases (such as Parkinson's disease or stroke), or have mental illness or visual impairments will be excluded. This study hopes to provide empirical data on eye movement signals and cognitive function in healthy older individuals, as well as to serve as a preliminary study for future development of eye activity stimulation to improve cognitive function in older adults.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • - Participants are aged 65 years or older and have completed a comprehensive geriatric assessment (CGA) in the outpatient clinic.

排除标准

  • Participants are under 65 years of age or those who ar are unable to comply with study procedures.

研究组 & 干预措施

Healthy group-patients with intact cognitive function

Mild cognitive impairment group-patients with mild cognitive impairment

Dementia group-patients with severe cognitive impairment

结局指标

主要结局

Eye-tracking measurement

时间窗: A single assessment is conducted at one study visit (cross-sectional design).

Eye movement behavior will be assessed as an objective measure of cognitive control in older adults. Eye-tracking data will be collected using the J7EF Gaze Smart Glasses (Jorjin Technologies), a non-invasive wearable eye-tracking system with a sampling frequency of 30 Hz. Participants will perform standardized visual tasks while eye movement behavior is recorded. Outcome measures will include task-related eye movement patterns, such as gaze behavior and saccadic performance, which reflect attentional control and higher-order cognitive processing. Alterations in these eye movement parameters have been associated with cognitive impairment. Eye movement measures will be used to characterize differences in cognitive function across participant groups.

次要结局

  • Mini-Mental State Examination (MMSE)(A single assessment is conducted at one study visit (cross-sectional design).)

研究者

发起方
National Sun Yat-sen University
申办方类型
Other
责任方
Sponsor

研究点 (1)

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