Effects of Different Ventilatory Strategy on Intraoperative Atelectasis During Bronchoscopy Under General Anesthesia.

Guangzhou Institute of Respiratory Disease1 site in 1 country60 target enrollmentFebruary 8, 2023

ConditionsLung Disorder

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Lung Disorder
Sponsor: Guangzhou Institute of Respiratory Disease
Enrollment: 60
Locations: 1
Primary Endpoint: Presence or absence of new atelectasis for each segment
Status: Not yet recruiting
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This trial compares two different types of ventilation for the prevention of partial or complete collapsed lung (atelectasis) in patients undergoing interventional pulmonology procedures under general anesthesia. Ventilatory strategy to prevent reduce the intra-procedural development of atelectasis during interventional pulmonology procedures under general anesthesia.

Registry

clinicaltrials.gov

Start Date

February 8, 2023

End Date

March 18, 2025

Last Updated

3 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Guangzhou Institute of Respiratory Disease

Responsible Party

Principal Investigator

ShiYue Li

Director of Department of Respiratory Medicine

Guangzhou Institute of Respiratory Disease

Eligibility Criteria

Inclusion Criteria

•Adult patients undergoing interventional pulmonology procedures with radial probe endobronchial ultrasound (RP-EBUS) for peripheral lung lesions
•Recent (\< 4 weeks) chest computed tomography (CT) performed prior to the bronchoscopy

Exclusion Criteria

•Patients with baseline lung consolidation, interstitial changes or lung masses (\> 3 cm in diameter) in dependent areas of the lung (right/left \[R/L\] B6, 9, or 10 bronchial segments) as seen on most recent CT
•History of primary or secondary spontaneous pneumothorax

Outcomes

Primary Outcomes

Presence or absence of new atelectasis for each segment

Time Frame: During bronchoscopy, an average of 1 hour.

The proportion of patients identified as developing intraprocedural atelectasis by radial probe endobronchial ultrasound (RP-EBUS)

Secondary Outcomes

Ventilation-induced complications(Within 48 hours of bronchoscopy)
Bronchoscopy-induced complications(Within 48 hours of bronchoscopy)
Assess the regional ventilation distribution by Electrical impedance tomography (EIT)(During bronchoscopy, an average of 1 hour.)