Comparison of lactate values obtained from different sites and its clinical significance in patients with severe sepsis: an observational study

Not Applicable

Completed

• Conditions: perfusion in sepsis; Metabolic and Endocrine - Other metabolic disorders

• Registration Number: ACTRN12610000128099
• Lead Sponsor: niversidade Federal de Sao Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-02-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

This is a cross-sectional study involving patients admitted at the intensive care unit of a tertiary university hospital who were diagnosed with severe sepsis and septic shock, according to the definitions of the 1992 American College of Chest Physicians/Society of Critical Care Medicine (ACCP/SCCM) consensus.16 Organ dysfunction should be acutely associated with the sepsis episode Patients could be included if they met the following inclusion criteria: onset of organ dysfunction within less than 24 hours of the first sample collection, indication for or presence of a central venous catheter, signature of an informed consent term by the patient or his/her legal representative and age over 18 years

Exclusion Criteria

The exclusion criteria were the presence of chronic or acute hepatic failure and the need for dialysis.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of lactate values. Pearson?s correlations will be calculated using arterial lactate as a reference for comparison both with central venous lactate and peripheral lactete. The results will be expressed through the correlation coefficient (R) and the descriptive level (p) to test its significance. Additionally, the Bland and Altman test will be used to determine the bias and the limits of agreement between central venous and peripheral lactate compared with the reference value (arterial). The results of Bland Altman test will be expressed in bias ? standard deviation (confidence interval 95%), with this confidence interval representing the limits of agreement.[measured after 6 months of the study]

Secondary Outcome Measures

Name	Time	Method
nil[nil]