Study of Placental Function in Healthy and Pathological Pregnancies
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 1,250
- Locations
- 1
- Primary Endpoint
- Collecting, processing, and archiving human specimens from 1250 subjects
Study Overview
Brief Summary
The purpose of this study is to establish a tissue and data repository consisting of samples of human placentas, umbilical cord blood, and maternal blood, collected at the time of delivery. Specimens will be used in cellular, molecular, and functional studies to learn more about changes in placental structure and function, which can result in serious pregnancy complications and determine life-long health by programming the fetus for future metabolic and cardiovascular disease.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy women delivering at term
- •Women with pregnancy complications such as:
- •pre-term birth,
- •intrauterine growth restriction,
- •diabetes, and
Exclusion Criteria
- •under stress,
- •experiencing pain of labor.
- •Pregnancies complicated by other pathologies.
Outcomes
Primary Outcomes
Collecting, processing, and archiving human specimens from 1250 subjects
Time Frame: Specimens will be stored for 50 years in repository
Human placental tissue, umbilical cord blood, and maternal blood samples will be collected from pregnant women at the time of their delivery. The samples will be used to enhance understanding of the role of the placenta in the development of pregnancy complications and in programming of adult disease.
Secondary Outcomes
No secondary outcomes reported