Cricopharyngeal Dysfunction in Adults
- Conditions
- Upper Esophageal Sphincter
- Registration Number
- NCT03598933
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
The objective of the study, after reviewing the recent literature, is to corroborate the thesis of the authors considering the injection of botulinum toxin as a gesture that is both diagnostic and therapeutic in the disorders of the Upper Esophageal Sphincter and reinforce the results already published with a larger series of patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
- Man or woman whose age older than 18 years
- Dysphagia with solids and / or liquids
- Dysfunction of primary or secondary Upper Esophageal Sphincter with indirect video-fibroscopy and / or video-fluoroscopy and / or high resolution pharyngo-oesophageal manometry
- Subject having at least one injection of botulinum toxin A in the crico-pharyngeal muscle for Upper Esophageal Sphincter dysfunction in the ENT department and cervico-facial surgery of Hautepierre.
- Subject who has consented to the use of his data from his medical file for the purpose of this research
Exclusion Criteria
- Myotomy in the first place
- Refusal of the subject to participate in the study
- Subject under the protection of justice
- Subject under guardianship or curatorship
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Deglutition Handicap Index The period from January 1st, 2017 to December 31st, 2017 will be examined
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie cricopharyngeal dysfunction in upper esophageal sphincter disorders?
How does botulinum toxin injection compare to standard-of-care treatments for cricopharyngeal dysfunction?
Are there specific biomarkers that predict response to botulinum toxin in upper esophageal sphincter disorders?
What are the known adverse events associated with cricopharyngeal botulinum toxin injections and how are they managed?
What combination therapies or alternative compounds are being explored for cricopharyngeal dysfunction alongside botulinum toxin?
Trial Locations
- Locations (1)
Service ORL et chirurgie cervico-faciale
🇫🇷Strasbourg, France
Service ORL et chirurgie cervico-faciale🇫🇷Strasbourg, FrancePhilippe Schultz, MD, PhDPrincipal InvestigatorSophie Gorostis, MDSub Investigator