NCT02588196Unknown4 期
The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis
Hui Bu0 个研究点目标入组 200 人开始时间: 2015年11月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 200
- 主要终点
- MRI
研究概览
简要总结
The study aimed to evaluate the relationships between the gene polymorphisms of leukotriene A4 hydrolase(LTA4H) and Dexamethasone treatment for tuberculous meningitis in Chinese patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 14 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients were eligible to enter the study if they met the diagnositic criteria for possible, probable or definite Tuberculosis meningitis(TBM).
排除标准
- •Patients were excluded if they were infected with HIV, diagnosed as carcinomatous meningitis, viral meningitis, purulent meningitis, cryptococcus meningitis.
研究组 & 干预措施
treatment of dexamethasone group
Experimental
干预措施: Dexamethasone acetate (Drug)
结局指标
主要结局
MRI
时间窗: 6 month
whether MRI show infarction, hydrocephalus, meningeal enhancement
changes of clinical symptoms
时间窗: 1 year
headache duration, duration of fever,presence of cranial nerve damage
changes of cerebrospinal fluid
时间窗: 1 year
次要结局
未报告次要终点
研究者
Hui Bu
chief physician
Hebei Medical University
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