Role of the Neonatal Fc Receptor for IgG in the Pathophysiology of Lupus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Expression of FcRn in active or newly diagnosed lupus erythematosus compared with inactive lupus erythematosus
研究概览
简要总结
This study evaluates the expression of the neonatal fc receptor (FcRn) in white blood cells and antigen-presenting cells (APC) in active lupus patients compared to inactive lupus patients and control to investigate if it's upregulated or not.
详细描述
FcRn is an intracellular receptor which binds the Fc of immunoglobulins G (IgG) and albumin which induce an upgraded half-life of this two proteins.
It's extended role involve the regulation of immune complexes and anti-tumoral immunity, some studies showing a direct correlation between it's expression and the tumor surface and prognosis.
Recently a role in the upregulation of humoral response with a increase of the antibodies's diversity and a more efficient priming of lymphocyte B have been evocated.
The lupus erythematosus is an auto-immune disease mediated by IgG and immune complexes characterized by a high diversity of autoantibodies and a large dysregulation of the immune system in all it's components.
In this study, by analogy with the founding in anti-tumoral immunity, the investigators hypothesised that in an active lupus disease the expression of FcRn is upregulated in the white blood cells and in APC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Expression of FcRn in active or newly diagnosed lupus erythematosus compared with inactive lupus erythematosus
时间窗: At baseline
Measurement in flow cytometry of the fluorescence's mean of FcRn in each type of white blood cells
次要结局
- IGHG1 genotyping(At baseline)
- Expression of FcRn in CD16 monocytes(At baseline)
- Expression of FcRn in macrophages(At baseline)
- FcRn genotyping (FCGRT)(At baseline)