Promoting Immune Health by Intermittent
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Immune health
研究概览
简要总结
The goal is to study the direct effects of long-term intermittent fasting on immune cell populations in the blood, combined with analyses of systemic metabolic fitness and inflammatory activation of leukocytes.
详细描述
the investigators aim to investigate the direct effects of intermittent fasting on the molecular characteristics of monocytes and their related health benefits. In addition,the investigators want to assess the post-prandial inflammation and the potential protective role of IF on post-prandial monocyte activation and its related health benefits. This pilot study may better understand the molecular mechanisms behind IF, which could further personalize lifestyle guidance and identify novel anti-inflammatory processes that control immune responses and inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
盲法说明
Investigators analysing study outcomes will be blinde
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Immune health
时间窗: 0-2 weeks
measured by transcriptomic assays for immune phenotyping
inflammatory activation of leukocytes
时间窗: 0-2 weeks
measured by flow cytometry
次要结局
- The effect of IF on glucose tolerance(2 hours and 0-2 weeks)
- The effect of Impaired fasting on gut microbiota composition.(0-2 weeks)
- effect on appetie(0-2 weeks)
- The effect of IF on the transcriptional and epigenetic repertoire of whole blood monocytes by stimulation assays(0-2 weeks)
- The effect on energy expenditure(2 hours)
- Changes in post-prandial bile acid metabolism(2 hours)
- Effect on Body composition and Appetite (visual analog scale scores + quantity of food consumed)(0-2 weeks)
研究者
Max Nieuwdorp
professor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)