Clinical Efficacy of Novel Biogenically Fabricated Titania Nanoparticles Enriched Mouth Wash in Treating the Tooth Dentine Hypersensitivity: a Randamized Clinical Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 130
- Locations
- 1
- Primary Endpoint
- Post mouth wash utilization Dentine Hypersensitivity
Study Overview
Brief Summary
Randomized Clinical trial to compare the reduction in dentin hypersensitivity after incorporating biogenically fabricated titania nanoparticles enriched Mouth Wash and Conventional Mouth Wash.Participants ranging between 20-50 years were allocated in two groups. Group A will use Conventional Mouth Wash without Nanoparticles. Group B will use titania nanoparticles enriched Mouth Wash. Both will use them for three months and then their VAS scoring will be checked.
Detailed Description
In this study Novel biogenically fabricated titania nanoparticle reinforced Mouth Wash will be evaluated for dentine sensitivity . Participants following Inclusion criteria will be allocated in this study by Consecutive random sampling technique. Participants will be divided into two groups i.e Group-A and Group-B with dentin sensitivity of 30-80. Group A will be given Conventional Mouth Wash for three months and Group-B will be given titania nanoparticles enriched Mouth Wash for three months for the sensitivity. Sensitivity will be assessed using Visual analog scale (VAS) mean score after 1 month and then three months.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Outcomes Assessor)
Masking Description
This is a triple-blinded study in which the participant, care provider and outcome assessor will be masked
Eligibility Criteria
- Ages
- 20 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Participants ranging between 20-50 years, good general health but developed dentine sensitivity associated with tooth surface wear and loss during the past 6 months.
- •There was no history of allergy.
- •Participants did not use any mouth wash , dentifrice or medication in the last 3 months.
- •The involved teeth were viable, non-shaky, devoid of any decay, cracks and fillings.
- •There was an essential positive response to the provoking Air stimuli.
- •These teeth should display the visible signs of tooth loss and wear such as : attrition, abrasion, erosion and abfraction.
Exclusion Criteria
- •Participants that might have developed allergy or used medications during the last 2 weeks or more.
- •The teeth having cracks, decay and fillings were also excluded. Patients who have undergone any periodontal surgery or gross periodontal issues.
- •Participants who used any desensitisizing toothpastes/mouthwashes and tooth bleaching agents within 2 months of the trial were also excluded positively.
Arms & Interventions
Group-A: Conventional Mouth wash .
Group A will receive conventional mouthwash for treatment of dentin hypersensitivity
Intervention: Group- A Conventional Sensed Mouth Wash (Procedure)
Group-B: Novel Titania nanoparticles Mouth wash
Group B will receive novel Titania nano particles reinforced mouthwash for treatment of dentin hypersensitivity
Intervention: Group-B Novel Titania nanoparticles enriched Mouth Wash (Procedure)
Outcomes
Primary Outcomes
Post mouth wash utilization Dentine Hypersensitivity
Time Frame: 3 months
Evaluation of dentine hypersensitivity with Conventional Mouth Wash without titania nanoparticles and Novel Nps Mouth Wash with titania nanoparticles on human tooth dentin. Visual analog scale with scoring from 0 to 100 where Score 100 means worst outcomes.
Secondary Outcomes
No secondary outcomes reported
Investigators
Afsheen Mansoor
Principal Investigator
Pakistan Institute of Medical Sciences