Measuring and strengthening immunity to measles in young adults fully immunised in childhood - single arm challenge study

niversity of Otago0 个研究点目标入组 100 人开始时间: 2023年2月9日最近更新: 2023年2月13日

试验速览

暂无简介。

•*Seropositive: Antibody above threshold for positivity of the Diasorin or BioPlex assay (for Dunedin and Auckland diagnostic labs, respectively) for both of measles and mumps antibodies and not required to have a dose of MMR vaccine by University of Otago or University of Auckland Screening and Immunisation Policies
•*Capable and willing to give written informed consent
•*Residing in Dunedin or Auckland
•*Able and willing to participate for the duration of the study visits and follow-up
•*Willing to provide verifiable identification at study entry and follow-up visits
•*Daily access to an internet-connected device (smart phone, tablet, laptop or PC) and willing to complete an electronic diary post vaccination.

•Contraindications to MMR as specified in the NZ Immunisation Handbook. These include:
•proven anaphylaxis to the vaccine or vaccine component (eg, neomycin or gelatin)
•significant immunocompromise: impaired cell-mediated immunity, including untreated malignancy, type 1 interferon receptor (IFNAR) signalling pathway defects, immunosuppressive drug therapy, including high-dose steroids, receiving high-dose radiotherapy, HIV infection with severely impaired T cell immunity
•another live vaccine, including Bacillus Calmette-Guérin (BCG), within the previous 4 weeks
•pregnant women – pregnancy should be avoided for four weeks after immunization
•participants pregnant during study participation may complete follow-up.
•intravenous immunoglobulin or blood transfusion during the preceding 11 months

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