Assistant Professor of Anesthesia, Intensive Care and Pain Management
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- number of patients (percentage) having intraoperative systolic hypertension
研究概览
简要总结
opioid free anesthesia consists of combination of pharmacological and non pharmacological modalities that target different pathways of pain mechanism. combining myofascial plane blocks with infusion of adjuvants such as lidocaine or dexmedetomidine can offer equivalent intraoperative hemodynamic stability compared to that of opioid with better pain control postoperatively. this study will investigate the efficacy of combined erector spina block with lidocaine and dexmedetomidine infusion as opioid sparing anesthesia in spine surgeries
详细描述
patients who will undergo spine surgery will be allocated into two groups. after general anesthesia, bilateral erector spine block will be applied in both groups. group A will have intraoperative fentanyl infusion and group B will have lidocaine and dexmedetomidine infusion in 50 ml syringe till end of surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •spine surgery ASAI,II
排除标准
- •revision surgery hypotension bradycardia
研究组 & 干预措施
traditinal balanced anesthesia
fentanyl infusion after general anesthesia and erector spinea block
干预措施: fentanyl infusion after general anesthesia and erector spinea block (Drug)
opioid free anesthesia
lidocaine and dextometidine infusion after general anesthesia and erector spinea block
干预措施: lidocaine 2% and dextometometidine infusion after general anesthesia and erector spinea block (Drug)
结局指标
主要结局
number of patients (percentage) having intraoperative systolic hypertension
时间窗: during operation(intraoperatively)
blood pressure more than 160 mmhg
number of patients(percentage) having tachycardia
时间窗: during operation(intraoperatively)
heart rate more than 100 beat /minute
次要结局
- VAS score(every 30 minutes for 2 hours postoperatively)
- incidence of bradycardia(intraoperatively)