Clinical Safety Study of Human Embryonic Stem Cell Derived Mesenchymal Cells in the Treatment of Moderate and Severe Intrauterine Adhesions

Qi Zhou0 sites32 target enrollmentJanuary 2020

ConditionsIntrauterine Adhesion

Overview

Phase: Phase 1
Intervention: Not specified
Conditions: Intrauterine Adhesion
Sponsor: Qi Zhou
Enrollment: 32
Primary Endpoint: Incidence of different Adverse Events of transplantation of mesenchymal cells from human embryonic stem cells
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

To observe the clinical safety of intrauterine injection of human embryonic stem cell derived mesenchymal cells in the treatment of moderate and severe intrauterine adhesion, and to preliminarily explore its clinical effectiveness in promoting endometrial regeneration and repair.

Detailed Description

In this study, a single-center, controlled, open-label design was used for a dose escalation study.To observe the clinical safety of intrauterine injection of human embryonic stem cell derived mesenchymal cells in the treatment of moderate and severe intrauterine adhesion, and to preliminarily explore its clinical effectiveness in promoting endometrial regeneration and repair.

Registry

clinicaltrials.gov

Start Date

January 2020

End Date

January 2022

Last Updated

6 years ago

Study Type

Interventional

Study Design

Single Group

Sex

Female

Investigators

Sponsor

Qi Zhou

Responsible Party

Sponsor Investigator

Principal Investigator

Qi Zhou

Director of Institute of zoology, chinese academy of sciences, and vice president of medical school， University of chinese academy of sciences

Chinese Academy of Sciences

Eligibility Criteria

Inclusion Criteria

•18 ≤ age ≤38, female;
•According to the 1988 American Fertility Society (AFS) diagnostic criteria, patients with uterine adhesions diagnosed with full civil capacity and with a score of ≥5 were enrolled in the study;
•The patient had one or more of the following clinical symptoms: reduced menstruation or amenorrhea, periodic abdominal pain, secondary infertility, recurrent abortion, premature delivery and other adverse pregnancy outcomes;
•The uterus was smaller than 8 weeks gestation and the uterine cavity depth was less than 12 cm;
•The second to fifth day of menstruation FSH \<10mIU/mL, AMH \>1.2ng/mL, AFC\>6;
•Understand and sign informed consent voluntarily.

Exclusion Criteria

•Patients with acute pelvic inflammation or endometriosis;
•Having or having a history of malignancy;
•Thrombus, lupus erythematosus and other hormone use contraindications; Allergic to albumin products;
•Patients with uterine malformation, adenomyosis, submucosal uterine fibroids,and uterine fibroids of any site \>5cm;
•Patients who were using anticoagulants or who had not recovered normal platelet function 10 days after discontinuation of antiplatelet drugs;
•Previous history of abnormal coagulation function or abnormality before cell transplantation;
•Always has a history of abnormal bleeding (such as abnormal bleeding during tooth extraction), or their immediate family members have hemorrhagic disease,such as hemophilia, bleeding symptoms (e.g., hematemesis, black, serious or recurrent nasal bleeding, coughing up blood, obvious hematuria, gastrointestinal bleeding, or intracranial hemorrhage), or suspected of vascular malformation such as aneurysm by researchers determine influence cell implant operation;
•Alcohol or drug addiction;
•Participated in other interventional clinical trials within 90 days before the informed consent was signed or before the cell transplantation;
•Had used glucocorticoids or immunosuppressive drugs within 12 weeks before signing the informed consent;