Vestibular Rehabilitation With Intratympanic Drug Therapy in Meniere's Disease

Not Applicable

• Conditions: Vestibular Disorder Preservation
• Interventions: Drug: Gentamicin; Drug: Dexamethasone

• Registration Number: NCT05355610
• Lead Sponsor: Combined Military Hospital Quetta

Brief Summary

Intractable symptoms of Meniere's disease will be treated with intratympanic steroids.

At the same time intratympanic dexamethasone will be used to rescue hearing

Detailed Description

For Alleviation of Intractable symptoms of Meniere's disease will be treated with intratympanic steroids. Measured with pre and post therapy vestibular severity index.

At the same time intratympanic dexamethasone will be used to rescue hearing measured with speech reception threshold and speech discrimination threshold

Study Timeline

• Study Start: 2021-04-01
• Status Verified: 2022-04
• Primary Completion: 2022-04-22
• Study First Submitted: 2022-04-24
• Study First Submitted QC: 2022-04-27
• Last Update Submitted: 2022-04-27
• Study First Posted: 2022-05-02
• Last Update Posted: 2022-05-02
• Study Completion: 2022-05-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 93

Inclusion Criteria

• All patients of unilateral Meniere's disease with severe vestibular symptoms

Exclusion Criteria

• Bilateral disease, operated cases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Vestibular severity index improvement	Gentamicin	Improvement in vestibular symptoms with intratympanic gentamicin
Vestibular severity index improvement	Dexamethasone	Improvement in vestibular symptoms with intratympanic gentamicin

Primary Outcome Measures

Name	Time	Method
Vestibular Rehabilitation	Three months	Improvement in vestibular severity index

Trial Locations

Locations (1)

CMH Quetta; 🇵🇰 Quetta, Balochistan, Pakistan