Physical Activity and Exercise in Urological Cancers Receiving Immune Check Point Inhibitor Treatment - a Qualitative Study Exploring Patient Perspectives and Experiences
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 12
- 主要终点
- Exploration of experiences
研究概览
简要总结
People who are diagnosed with a cancer commonly experience symptoms that affect day-to-day life, including muscle weakness, pain, tiredness and fatigue. These consequences can make it hard for people to tolerate their medical treatments.
It is well known that regular physical activity or planned exercise can help with these symptoms and significantly improve physical and mental health during cancer treatment. Recent animal studies suggest that exercise training can also reduce the number of cancer cells. For example, exercise training in mice produces more immune cells in the tumour. These immune cells in the tumour contribute to the destruction and reduction of the size of the tumour and are a vital component of effective immunotherapy (cancer treatment that helps your immune system fight cancer). In humans, exercise training and the effect on the immune response in tumours are less understood and is a new area being explored. However, we are aware that most people diagnosed with a cancer are not physically active, and especially not during the treatment period. The aim of this study is to understand the experiences and perceptions of physical activity and exercise in those with cancer receiving immunotherapy treatment (such as immune check point inhibitors (ICI). This will help us to create new practices or change practices to help those with cancer to partake in physical activity and exercise when on treatment.
Participants consenting to take part in the study will be individually interviewed through a semi-structured interview.
详细描述
Purpose and Design:
Immunotherapy drugs have transformed the landscape of cancer treatment in the last decade. New emerging evidence suggest when integrated with existing cancer treatments, exercise has a positive impact on tumour control, with preclinical studies reporting that exercise suppressed tumour growth and rate of recurrence when delivered as a standalone intervention. However, only 20% of people with cancer do sufficient levels of physical activity (PA) and or exercise to meet national guidelines. These activity levels are anticipated to be even less in those receiving active treatment.
While there is evidence which demonstrates barriers, facilitators and preferences to participation in physical activity and exercise for people with cancer, there is little understanding about these factors in cancer patients receiving active treatments such as immune check point inhibitors (a type of immunotherapy treatment). This is an exploratory study looking into the perspectives and experiences physical activity and exercise in people with cancer receiving immunotherapy treatment. The design implicitly involves people with cancer undergoing immunotherapy treatment.
Recruitment:
Potential participants will be identified by a member of their treating team at clinic outpatient appointments or by the patient self-contacting the research team from flyers and posters seen in outpatient clinics. The study will either be introduced during the same clinic by a member of the patients care team or by the research team via phone, following direct patient enquiry about the study. The purpose of the study will be explained, and the potential participant given an opportunity to ask questions about the proposed study. A patient information sheet will be provided. If interested the potential participant will be provided with a consent form and pre-screening questionnaire.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary Urological (Bladder and Renal) cancer diagnosis receiving or planned immune check point inhibitor treatment at GSTT hospital.
- •Adults aged 18 years or older
- •Willing and able to take part in Face to Face interviews at a hospital site or virtual video interviews at home.
- •Cancer survival >6 month
- •Proficient in English
排除标准
- •Aged lower than 18 years
- •Inability to give informed consent and information (due to unable to speak or understand English)
结局指标
主要结局
Exploration of experiences
时间窗: 3-6 months
To understand participant's perspectives and experiences of physical activity and exercise on immune check point immunotherapy treatment through Inductive thematic analysis of semi-structured individual interviews.
次要结局
未报告次要终点
研究者
Nicola Peat
Consultant Physiotherapist
Guy's and St Thomas' NHS Foundation Trust