Measuring Corneal Cells With Specular Microscopy
- Conditions
- Retinal Diseases
- Registration Number
- NCT01792154
- Lead Sponsor
- Retina Institute of Hawaii
- Brief Summary
Assess changes in the corneal cell count using Specular Microscopy following tretments with Anti-VEGF injections
- Detailed Description
Patients with active Wet AMD often receive intraocular Anti-VEGF injections such as Macugen, Lucentis and Avastin on a monthly basis for an extended period of time. While these medications are very effective at controlling the Choroidal Neovascularization associated with this disease, the impact of monthly intravigtreal Anti-VEGF injections on the viability of corneal endothelial cells has yet to be fully characterized. The availability of CESM as a diagnostic test that can be performed quickly and painlessly in the clinic offers a method of tracking corneal endothelial cell count in this patient population.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- Wet Age-related Macular Degeneration
- Receiving monthly intraocular injections of Anti-VEGF medication for at least 3 months
- Age greater than 50 years of age
- experiences adverse events
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Specular Photomicrographic Assessment of the Effect of Anti-VEGF Intravitreal injections on corneal thickness and endothelial cell density and morphology Baseline, Month 6 and Month 12 Changes in corneal endothelial cell density and corneal thickness measured by changes in pachymetry and corneal cell count.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Retina Institute of Hawaii
🇺🇸Honolulu, Hawaii, United States