ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells

Completed

Conditions: autoimmune vessel wall inflammation
vasculitis
10003816
10047066

Registration Number: NL-OMON37886

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 160

Inclusion Criteria

Over 18 years of age.
Study population:
Diagnosis Granulomatosis with polyangiitis (GPA; Wegener), or Microscopic polyangiitis according to the 1994 Chapel Hill Consensus conference
Positive at any time point for PR3- or MPO-ANCA.
Since patients can change from inactive to active patients over time, patients can be included at any time point in their disease course.;Control population:
Either any person who reports him or her selves as being healthy, does not use any immune modulating medication and wants to donate blood.
Or disease controls being diagnosed with Systemic Lupus Erythematosus, Rheumatoid Arthritis, Sjogren Syndrome or Giant Cell Arteriitis, as judged by the principle investigator.

Exclusion Criteria

Unable to consent
Unable to donate blood

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The difference of the number/function of the regulatory B cells in patients who<br /><br>relapse versus the patients that do not relapse, the disease controls and with<br /><br>the healthy controls. </p><br>

Secondary Outcome Measures