A multi-center clinical trial of tolerance induction using autologous regulatory T cells in liver transplantatio

Phase 2

• Conditions: End-stage liver failure patients eligible for liver transplantation

• Registration Number: JPRN-UMIN000030612
• Lead Sponsor: Hokkaido University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-01-01
• Study Completion: 2019-08-28
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

Not provided

Exclusion Criteria

Recipient 1. A person who has no recognition capacity 2. A person who is judged inadequate for the protocol due to the following past history or ongoing infections 1) Bacterial infection such as Treponema pallidum, Neisseria gonorrhea or Mycobacterium tuberculosis 2) Sepsis 3) Malignant diseases (except for hepatocellular carcinoma) 4) Severe metabolic diseases 5) Collagen disease or hematological disorders 6) Transmissible spongiform encephalopathy or dementia 7) A specific hereditary disease or associated familial history 8) Human immunodeficiency virus infection 9) Human T-cell leukemia virus type 1 infection 10) Human parvovirus B19 infection 11) Active infection such as Cytomegalovirus, Epstein-Barr virus or West e virus 3. A person 1) with systolic blood pressure under 90 mmHg or over 180 mmHg, 2) with diastolic blood pressure under 50 mmHg or over 100 mmHg 4. A person considered ineligible due to some medical reasons by principal investigator or co-researchers Donor 1. A donor who has no recognition capacity 2. A donor who is judged inadequate for the protocol due to the following past history or ongoing infections 1) Bacterial infection such as Treponema pallidum, Neisseria gonorrhea or Mycobacterium tuberculosis 2) Sepsis 3) Malignant diseases 4) Severe metabolic diseases 5) Collagen disease or hematological disorders 6) Liver diseases 7) Transmissible spongiform encephalopathy or dementia 8) A specific hereditary disease or associated familial history 9) HBV infection 10) HCV infection 11) Human immunodeficiency virus infection 9) Human T-cell leukemia virus type 1 infection 10) Human parvovirus B19 infection 11) Active infection such as Cytomegalovirus, Epstein-Barr virus or West e virus 3. A donor 1) with systolic blood pressure under 90 mmHg or over 180 mmHg, 2) with diastolic blood pressure under 50 mmHg or over 100 mmHg 4. A person considered ineligible due to some medical reasons by principal investigator or co-researchers

Study & Design

• Study Type: Interventional
• Study Design: Not specified