Effect of rTMS on HSP

Phase 3

• Conditions: Hereditary spastic paraplegia.; Hereditary spastic paraplegia; G11.4

• Registration Number: IRCT20170703034879N2
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 6 October 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Diagnosis based on Fink's Criteria
Signed written informed consent

Exclusion Criteria

History of Seizure
Uncontrolled hypertension
Cochlear implant
Cardiac Pacemaker
Foreign body in patient's body

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement of lower limb spasticity based on modified Ashworth scale. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 moth after intervention. Method of measurement: Modified Ashworth Scale (MAS).

Secondary Outcome Measures

Name	Time	Method
Change in patients' mobility based on 10-meter walking test. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 month after intervention. Method of measurement: 10-meter Walking test.;Change in motor function of lower limb. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 month after intervention. Method of measurement: Fugl-Meyer Assessment of lower limb (FMA-LE).;Quality of Life. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 month after intervention. Method of measurement: Short form survey 36 (SF-36).