A Pilot Study to Identify Biomarkers Associated With Chronic Traumatic Brain Injury
- Conditions
- Traumatic Brain Injury
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 96
Chronic TBI patients:<br><br>Inclusion Criteria<br><br>Have a history of head trauma manifesting in one or more of the following:<br><br> - Loss of consciousness<br><br> - Post-traumatic amnesia<br><br> - Focal neurologic deficits, seizure<br><br> - Persistent symptoms of increased arousal (e.g. difficulty falling or staying asleep,<br> anger and hypervigilance)<br><br> - Impairment in social, occupational, or other important areas of functioning (e.g.<br> problems with work and relationships.)<br><br>Exclusion Criteria<br><br>Inability to obtain informed consent and if they are non-communicative (i.e. in a<br>vegetative state).<br><br>Healthy volunteers:<br><br>Inclusion Criteria<br><br> - No significant medical history<br><br> - Take no medications (other than birth control pills)<br><br> - Fever free<br><br> - No history of head trauma or recent injury/infection<br><br> - No history of neurological or psychiatric disorders or alcohol or drug dependency.<br><br>Exclusion Criteria<br><br> - Inability to provide informed consent<br><br> - age/gender match not available in TBI cohort
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proteomic analysis of plasma
- Secondary Outcome Measures
Name Time Method Proteomic analysis of saliva