Atrial Fibrillation and Non-obstructive Coronary Lesions

Completed

• Conditions: Fibrillation, Atrial; Chronic Kidney Diseases; Coronary Artery Disease
• Interventions: Procedure: Coronary angiography

• Registration Number: NCT04537507
• Lead Sponsor: Medical University of Bialystok

Brief Summary

Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with excessive risk of ischemic stroke and heart failure as well as reduced life expectancy. On the other hand, chronic coronary syndromes (CCS) remains the main cause of morbidity and mortality in an aging population. Both disease entities share common risk factors such as hypertension, diabetes and obesity The purpose of the study is to investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.

Detailed Description

Atrial fibrillation (AF) and chronic coronary syndromes (CCS) share common risk factors and both disease entities frequently co-exist. Additionally, AF symptoms may mimic CCS. Objectives: To investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.

The prevalence of CCS in patients with AF varies from 17% to 47% whereas AF in patients with CCS is much less common, ranging from 0.2% to 5.Patients with AF more often have concomitant CCS as compared with sinus rhythm controls. Additionally, AF is more frequently present in patients with either peripheral- or cerebrovascular artery disease than in non-atherosclerotic individuals We conducted a multi-center retrospective study including consecutive patients referred for elective coronary angiography.

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2020-08-22
• Study First Submitted QC: 2020-09-02
• Study First Posted: 2020-09-03
• Status Verified: 2021-09
• Primary Completion: 2021-12
• Study Completion: 2022-01
• Last Update Submitted: 2022-01-06
• Last Update Posted: 2022-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8000

Inclusion Criteria

• Coronary angiography

Exclusion Criteria

• We excluded patients with acute coronary syndromes (ACS), Tako-tsubo cardiomiopathy and history of ischemic heart disease, as well as those referred for coronary angiography before heart valve surgery. Prior cardiosurgical valve replacement was also the exclusion criterion.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients underwent coronary angiography	Coronary angiography	We reviewed medical notes of patients hospitalized for coronary angiography because of exacerbated angina (recurrent chest pain, classical stable angina, long history of chest pain/angina or other symptoms such as dyspnea). We excluded patients with acute coronary syndromes (ACS), Tako-tsubo cardiomiopathy and history of ischemic heart disease, as well as those referred for coronary angiography before heart valve surgery. Prior cardiosurgical valve replacement was also the exclusion criterion.

Primary Outcome Measures

Name	Time	Method
Coronary artery disease	Through study completion, an average of 8 years	Number of Participants with significant findings on coronary angiography

Trial Locations

Locations (5)

Medical Univeristy of Bialystok; 🇵🇱 Bialystok, Poland

Department of Cardiology, Medical University of Bialystok, Bialystok, Poland; 🇵🇱 Białystok, Poland

Department of Cardiology and Internal Medicine, Medical University of Gdansk, Gdynia, Poland; 🇵🇱 Gdansk, Poland

Department of Internal diseases, I.M.Sechenov First Moscow State Medical University, Moscow, Russian Federation; 🇷🇺 Moscow, Russian Federation

iverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; 🇬🇧 Liverpool, United Kingdom