Effects of obeticholic acid on hepatic fatty acid/triglyceride metabolism and hepatobiliary detoxification/elimination in morbidly obese and gallstone patients. - OCABSGS

Sahlgrenska Academy0 个研究点开始时间: 2011年3月3日最近更新: 2012年8月14日

适应症

试验速览

暂无简介。

•Age20 to 65 years;
•in the obesity group: BMI =35 kg/m2
•in the gallstone group: symptomatic, ultrasound verified gallstone disease
•SexMales, pre-, and post-menopausal females
•DiagnosisPatients eligible to laparoscopic bariatric and gallstone surgery, respectively
•ConsentPatients should have given their written consent to participate in this study
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years)
•F.1.3.1 Number of subjects for this age range

•Chronic liver disease other than NAFLD (viral hepatitis, autoimmune liver disease, hemochromatosis, homozygous alpha1-antitrypsin deficiency and Wilson disease)
•Previous gastric or small bowel surgery
•Inflammatory bowel disease
•Uncontrolled diabetes mellitus (fasting blood glucose >6.7 mmol/L),
•hypothyroidism or hyperthyroidism, or other significant endocrine disease (a subject who is euthyroid on a stable replacement dose of thyroid hormone is
•acceptable provided the TSH is within normal range).
•Other serious disease, including depressive disorders treated by medication
•Patients who will not comply with the protocol.
•Pregnancy. Women in childbearing age must adhere to secure anticonception

发起方

Sahlgrenska Academy