Facilitating Motor Skill Learning by Aerobic Training in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 2
- 主要终点
- Motor Learning (Precision)
研究概览
简要总结
The study is designed to assess the effects of aerobic exercise on motor learning in Parkinson patients. Specifically, the investigators examine whether a single bout of moderate intensity aerobic exercise, performed immediately before task practice, facilitates the acquisition and retention of a motor skill. In a cross-over design, participants will be randomly allocated to either the intervention group (aerobic exercise before motor learning) or control group (rest before motor learning).
详细描述
Parkinson's disease is a progressive neurodegenerative disorder that is characterized by motor control impairments, such as gait disturbances and postural instability. Beneficial effects of exercise are attributed to mechanisms of neuroplasticity, and task-specific motor training is consequently considered to be a motor learning process. While motor learning is preserved in persons with Parkinson's disease, slower acquisition rates and reduced retention have been reported compared to healthy individuals.
Thus, it is crucial to identify strategies to enhance motor learning in people with Parkinson's disease. Recent studies have accumulated evidence to show that aerobic exercise can facilitate motor skill learning. However, these observations are limited to healthy individuals and have not been addressed in individuals with neurologic conditions.
The present study is designed to assess the effects of a single bout of moderate intensity aerobic exercise on a motor skill learning task in patients with Parkinson's disease.
In a cross-over design, participants will be randomly allocated to one of two groups. Both groups will practice balancing on a specific stability platform (motor learning task). The experimental group will additionally perform a bout of aerobic exercise (cycle ergometer) immediately before the motor learning task, while the control group will rest before practice. Subsequently, the acquisition and one-day retention of the motor learning task will be examined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parkinson's disease stage 1-3 on Hoehn & Yahr scale
- •Ability to stand unaided and walk without an assistive device
- •Stable medication during the study period
排除标准
- •On-off and wearing-off phenomena
- •Unstable medical or psychiatric illness
- •Clinically relevant cardiovascular or orthopaedic disease
- •Severe polyneuropathy
- •Cognitive impairment
- •Smoking > 10 cigarettes/day
- •Caffeine > 6 cups of coffee/day
- •Alcohol > 50 g (two glasses)/day
研究组 & 干预措施
aerobic exercise + motor skill practice
acute bout of aerobic exercise before motor learning
干预措施: aerobic exercise (Behavioral)
aerobic exercise + motor skill practice
acute bout of aerobic exercise before motor learning
干预措施: motor learning (Behavioral)
rest + motor skill practice
seated rest before motor learning
干预措施: rest (Behavioral)
rest + motor skill practice
seated rest before motor learning
干预措施: motor learning (Behavioral)
结局指标
主要结局
Motor Learning (Precision)
时间窗: Baseline (first trial of practice day 1), 1 day (last trial of practice day 1), and 7 days (first trial of 7-day retention session).
Change from baseline in time in balance (±5° from horizontal) during balancing task.
次要结局
- Motor Learning (Variability)(Baseline (first trial of practice day 1), 1 day (last trial of practice day 1), and 7 days (first trial of 7-day retention session).)
研究者
Simon Steib, PhD
Dr.
University of Erlangen-Nürnberg