Neural Correlates of Real World Spatial Navigation in Humans
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 70
- 试验地点
- 3
- 主要终点
- Oscillatory activity change
研究概览
简要总结
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None (Participant, Investigator)
入排标准
- 年龄范围
- 12 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •12 years of age or older and has undergone RNS system placement
- •Willing to provide informed consent and participate the study
- •Ability to read and write English fluently
排除标准
- •Unwilling to provide informed consent
研究组 & 干预措施
RNS Participants
Subjects with RNS implants.
干预措施: Deep Brain Stimulation (Device)
RNS Participants
Subjects with RNS implants.
干预措施: Memory and spatial navigation tasks (Behavioral)
RNS Participants
Subjects with RNS implants.
干预措施: Physiological Signals (Behavioral)
RNS Participants
Subjects with RNS implants.
干预措施: Questionnaires and Assessments (Behavioral)
结局指标
主要结局
Oscillatory activity change
时间窗: Throughout study completion, an average of 2-4 days per year
Changes in theta, gamma, and theta-gamma coupling will be measured both in relation to changes in memory performance on trials with and without deep brain stimulation as well as in relation to body, head, and eye position in a virtual, augmented, or real-world environment.
Spatial memory
时间窗: Throughout study completion, an average of 2-4 days per year
Spatial memory will be measured using virtual, augmented and real-world spatial navigation tasks where participants will be asked to navigate a previously learned rout as well as if they recognize objects (i.e. landmarks) that appeared along the route (photos of seen landmarks vs unseen landmarks).
Memory performance change
时间窗: Throughout study completion, an average of 2-4 days per year
Memory performance will be measured using excess path length, latency, and accuracy rate.
次要结局
未报告次要终点
研究者
Nanthia Suthana
Assistant Professor
University of California, Los Angeles