Discovery and validation of diagnostic biomarkers for left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fractio

Completed

Conditions: 10019280
Diastolic Heart Failure
Heart failure with preserved ejection fraction

Registration Number: NL-OMON50536

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 977

Inclusion Criteria

- Patients in the cardiology outpatient clinic of Cardiology Centre
Netherlands, Diakonessenhuis Utrecht or HeartLife Klinieken Utrecht who
receive cardial screening, including an echocardiography, because of general
practitioner*s request
- Age 45 year and older
- Patient is willing and able to provide written informed consent for
participation in this study
- The inclusion criteria match the criteria for diagnosis of diastolic
dysfunction or HFpEF., Additional ARGUS, Inclusion criteria ARGUS
In order to be eligible to participate in the ARGUS study, a subject must meet
the additional following criterium:
• Chest pain as main symptom

Exclusion Criteria

• Patients from whom no informed consent is obtained
• Incapacitated adults: language barriers or other obstacles for full
understanding of the study objectives
• Patients with former cardiac procedures.
• Patients with congenital heart disease,

Additional ARGUS:
A potential subject who meets any of the mentioned criteria or any of the
following will be excluded from participation in the ARGUS study:
• Patients for whom (a part of) the cardiac CT study protocol is contra
indicated prior to inclusion (if CT is contra indicated after completion of
MRI-scan patient will not be excluded but collected data will be used in study)
• Patients for whom (a part of) the cardiac MRI study protocol is contra
indicated prior to inclusion (if MRI is contra indicated after completion of
CT-scan patient will not be excluded but collected data will be used in study)
• Participants who are referred for an intervention immediately after
completing the cardiac CT scan

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our primary aim is to improve the (early) diagnosis of diastolic dysfunction<br /><br>and HFPEF with the discovery and validation of new biomarkers. Since HFPEF is<br /><br>more prevalent in females, we will focus on discovery of sex-specific<br /><br>biomarkers..<br /><br><br /><br>Endpoint: diagnosis of grade of diastolic dysfunction (LVDD) confirmed by E/e*<br /><br>values or HFpEF<br /><br><br /><br>Additioneel ARGUS:<br /><br>To describe the prevalence of CAD and coronary microvascular disease (CMD) in a<br /><br>population of patients from the general population who are referred to the<br /><br>Cardiology Center Netherlands, location Utrecht or the Diakonessenhuis by their<br /><br>general practitioner and present with chest pain as the main symptom. </p><br>

Secondary Outcome Measures