NCT07045987Enrolling By Invitation不适用
FUtile Reperfusion in acuTe iscHEmic stRoke- FURTHER
Xijing Hospital1 个研究点 分布在 1 个国家目标入组 2,000 人开始时间: 2025年6月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- 3-month mRS score
研究概览
简要总结
The goal of this prospective cohort registration study is to establish an early warning system for futile recanalization in acute ischemic stroke by analyzing multi-omics information to identify key regulatory nodes and target molecules in ineffective recanalization.
The core issue addressed by this research is: Identifying key regulatory nodes and target molecules closely associated with futile recanalization, revealing the interactions among the neurovascular unit, peripheral immune cells, and the brain lymphatic system, as well as developing early diagnostic biomarkers and novel diagnostic technologies for futile recanalization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged ≥18 years
- •Acute ischemic stroke confirmed by clinical and neuroimaging criteria (CT or MRI)
- •Clinical indication for thrombectomy
- •Provision of signed informed consent
排除标准
- •Preexisting dementia or severe disability (modified Rankin Scale score ≥3)
- •Cerebral vascular malformations, neoplasms, abscesses, or other significant non-ischemic brain pathologies
- •Life-limiting systemic comorbidities (e.g., end-stage organ failure, metastatic malignancies) with anticipated survival <6 months
- •Patient or legally authorized representative declined consent
- •Anticipated poor protocol adherence or loss to follow-up
结局指标
主要结局
3-month mRS score
时间窗: From enrollment to the end of treatment at 3 months
次要结局
未报告次要终点
研究者
研究点 (1)
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