Intraventricular infusion of rt-PA in severe intraventricular haemorrhage after aneurysmal subarachnoid haemorrhage. A randomised clinical trial.

Completed

• Conditions: Aneurysmal subarachnoid haemorrhage, Hydrocephalus, Intraventricular haemorrhage; Circulatory System; Other cerebrovascular diseases

• Registration Number: ISRCTN36786212
• Lead Sponsor: niversity Medical Center Utrecht, Department of Neurology (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01-27
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

1. First or recurrent aneurysmal subarachnoid haemorrhage with intraventricular extension of the haemorrhage
2. The ventricles must be enlarged and the intraventricular haemorrhage must be severe (Graeb-score more than 6)
3. Patients must be in a poor neurological condition, WFNS <7 or WFNS <6 in intubated patients

Exclusion Criteria

1. Other cause for intraventricular haemorrhage than a subarachnoid haemorrhage from a ruptured intracranial aneurysm
2. Absence of both pupillary light reflexes
3. Use of oral anticoagulants
4. Treating physicians propose a palliative instead of curative treatment strategy
5. Absence of informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified