MYocardial DOmmages Related to COVID-19

Completed

• Conditions: Myocarditis; Covid19; Non Ischemic Myocardial Injury; Myocardial Infarction; Troponin Elevation
• Interventions: Biological: Biological data; Other: Clinical data

• Registration Number: NCT04498065
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

Myocardial injury, as assessed by elevation of cardiac troponins (Tnc), is frequent among patients with COVID-19. Although rare autopsy cases reported COVID-19 related myocardial inflammation, the origin of Tnc elevation is unknown to date. Several cardiac causes, such as myocarditis, non-ischemic myocardial injury (NIMI), or myocardial infarction (MI) may lead to Tnc kinetic. Our work will test the hypothesis that during SARS-Cov2 infection, the elevation of cardiac biomarkers could be linked to the occurrence of myocarditis.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-01
• Study First Submitted: 2020-08-03
• Study First Submitted QC: 2020-08-03
• Study First Posted: 2020-08-04
• Primary Completion: 2022-05-31
• Study Completion: 2022-05-31
• Status Verified: 2022-09
• Last Update Submitted: 2022-09-20
• Last Update Posted: 2022-09-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 273

Inclusion Criteria

• COVID-19 positive patient hospitalized < 72 h after symptoms onset with troponin assessement.

Exclusion Criteria

• patients hospitalized > 72h after symptom onset

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
B	Biological data	COVID positive and Troponin negative
A	Clinical data	COVID positive and Troponin positive
A	Biological data	COVID positive and Troponin positive
B	Clinical data	COVID positive and Troponin negative

Primary Outcome Measures

Name	Time	Method
characterize the myocardial damage associated with CoV-2 SARS infection	Through study completion, an average of 2 years	Myocardtitis diagnosis in patients COVID+ and troponin+

Trial Locations

Locations (1)

Chu Dijon Bourgogne; 🇫🇷 Dijon, France