Comparison between intraarticular Platelet Rich Plasma and Adalimumab in improvement of pain, quality of life and activities of daily living in patients with primary osteoarthritis knee - NI

All India Institute of Medical Sciences0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年7月25日

试验速览

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•INCLUSION CRITERIA :
•1.Patients diagnosed with OA of knee based on American College of Rheumatology
•2.Radiologic KL grade II & III
•3. VAS Score > 40
•4. Patients not showing improvement with conservative treatment using NSAIDs for 3
•5.Patients willing for follow up

•EXCLUSION CRITERIA :
•1. Patients with cognitive impairment and psychiatric disorders
•2. Local site infections
•3. Uncontrolled diabetes
•4.Presence of other rheumatologic conditions, autoimmune diseases and collagen
•vascular disease
•5.Coagulation disorders and disorders affecting platelet
•6. Active and latent tuberculosis
•7. History of active, recurrent or chronic infections
•8. Congestive heart failure (NYHA class III and IV)
•9. Immunocompromised (HIV, Patients on immunosuppresants, transplant recipients)
•10. Previous use of TNF alpha inhibitors for Knee OA
•11. Platelet <1,50,000/microlitre
•12. Prior knee injections (like cortcosteroid, HA or prolotherapy) in past 3 months
•13. Previous knee surgery
•14..Use of systemic steroids within past 3 months
•15. Malignancy
•16. Pregnancy and lactation
•17. Individuals who refused to participate

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