The Effects of Three Different Ultrasound-guided Nerve Blocks in VATS

Not Applicable

• Conditions: Pain, Acute; Nerve Block; Thoracic Anesthesia
• Interventions: Procedure: Paravertebral block; Procedure: MTP block; Procedure: ESP block

• Registration Number: NCT04829409
• Lead Sponsor: Huazhong University of Science and Technology

Brief Summary

Ultrasound-guided mid-point transverse process to pleura block, erector spinae plane block and paravertebral block are three different methods of nerve block, used for relieving postoperative pain in thoracic anesthesia. This study is to compare them on block effects, postoperative pain and analgesic consumption in video-assisted thoracic surgery.

Detailed Description

Ultrasound-guided nerve block is an important part of multi-mode analgesia to decrease the consumption of opioids. Thoracic paravertebral block is considered as an ideal regional analgesic choice for video-assisted thoracic surgery, but it still has some side effects, such as pneumothorax, vascular injury, especially for novices. Recent years, ultrasound-guided mid-point transverse process to pleura block and erector spinae plane block are reported for thoracic surgery. The insertion depth in these two methods is more superficial than traditional paravertebral block. They could have less side effects. Therefore, we design a randomised control study to compare them on block effects, postoperative pain and analgesic consumption in video-assisted thoracic surgery.

Study Timeline

• Study First Submitted: 2021-03-30
• Study First Submitted QC: 2021-04-01
• Study First Posted: 2021-04-02
• Study Start: 2021-04-05
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-13
• Last Update Posted: 2022-04-14
• Primary Completion: 2022-10
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• selective lobetomy under VATS
• ASA classfication 1-3

Exclusion Criteria

• history of thoracic surgery
• double lateral VATS
• allergy to local anesthetics
• coagulation disorders
• severe heart diseases, hepatic or renal insufficiency
• a history of chronic pain or chronic opioid use
• psychiatric disease or uncooperative
• BMI>28 kg/m2
• VATS transfered to open thoractomy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
paravertebral block	Paravertebral block	Patients receive ultrasound-guided paravertebral block
MTP block	MTP block	Patients receive ultrasound-guided mid-point transverse process to pleura (MTP) block
ESP block	ESP block	Patients receive ultrasound-guided erector spinae plane (ESP) block

Primary Outcome Measures

Name	Time	Method
postoperative morphine consumption	postoperative 24 hours	The dose is according to the record from PCA pump

Secondary Outcome Measures

Name	Time	Method
Pain score at rest	at 0, 8, 24 hour after surgery	measured by VAS (0-10)
Pain score while coughing	at 0, 8, 24 hour after surgery	measured by VAS (0-10)

Trial Locations

Locations (1)

Tongji Hospital, Huazhong University of Science and Technology; 🇨🇳 Wuhan, Hubei, China