Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

Not Applicable

Recruiting

• Conditions: Gastroesophageal Reflux Disease; Proximal Gastric Adenocarcinoma; Gastric Cancer
• Interventions: Procedure: Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty

• Registration Number: NCT05514769
• Lead Sponsor: Nanchong Central Hospital

Brief Summary

This research is designed to compare proximal gastrectomy anterior anastomosis with pyloroplasty with esophagogastric anastomosis for gastric cancer. Gastroesophageal reflux disease, postoperative quality of life, short term outcomes, and long term outcomes will be compared.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-01
• Study First Submitted: 2022-08-21
• Study First Submitted QC: 2022-08-23
• Study First Posted: 2022-08-24
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-19
• Last Update Posted: 2025-03-25
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.
2. Eastern Cooperative Oncology Group performance status of 0 or 1.
3. Adequate organ function.

Exclusion Criteria

1. Patients had distant metastasis.
2. oesophageal invasion of more than 3 cm.
3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.
4. Previous chemotherapy or radiation therapy for any other malignancies.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty	The reconstruction including esophagogastric anastomosis and pyloroplasty for patients who underwent proximal gastrectomy . The anastomosis locate in the posterior or side of gastric stump.
Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty (GAP)	Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty	The reconstruction including esophagogastric anastomosis and pyloroplasty for patients who underwent proximal gastrectomy . The anastomosis locate in the anterior of gastric stump.

Primary Outcome Measures

Name	Time	Method
Gastroesophagus reflux disease apprised by ph monitoring	6 months	Ph monitoring by wireless or wire device
Gastroesophagus reflux disease apprised by questionnaire	6 months	PGSAS-45 questionnaire is adopted.

Secondary Outcome Measures

Name	Time	Method
Long-term outcome	5 years	Total survival time after proximal gastrectomy for gastric cancer
Surgical complications of proximal gastrectomy for gastric cancer	1 year	Surgical complications include anastomotic leakage, anastomotic stricture, postoperative bleeding, pleural effusion, et al.

Trial Locations

Locations (1)

Yunhong Tian; 🇨🇳 Nanchong, Sichuan, China