Study for EEG/MRI Brain Mechanism of ''Tonifying Sui and Arousing Shen'' Early Acupuncture Intervention for Post-Stroke Aphasia Based on Dual-Stream Model of Language Processing
- Conditions
- Post-stroke aphasiaR47.002
- Registration Number
- ITMCTR2100005230
- Lead Sponsor
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. Diagnosed as stroke, 14 to 30 days after stroke onset;
2. Aged 18 years and above, and native language is Chinese, right-handed;
3. Primary school and above education;
4. Definite aphasia syndrome, diagnosed as Non-fluent aphasia after stroke by WAB;
5. The score of Boston Diagnostic Aphasia Examination (BDAE) is 2 to 4;
6. The language function and orientation were normal before the onset, with the distal muscle strength of unilateral upper limb grades greater than or equal to grade IV;
7. Be able to cooperate one-hour EEG/MRI examination;
8. Signed informed consent is obtained according to local ethical committee requirements.
1. Severe hearing and visual impairment;
2. Superficial sensation abnormalities in the neurological examination;
3. Patients with dysarthria;
4. Language dysfunction caused by congenital or childhood diseases;
5. Patients who have received pacemaker surgery, coronary intervention, coronary artery bypass surgery and other metal products in the body, which cannot undergo MRI examination;
6. Patients who have serious heart, liver, and kidney diseases;
7. Patients with moderate or severe dementia, MMSE =< 20 points, education level above junior high school =< 24 points;
8. Patients who are unable to perform image naming task due to dysfunction such as agnosia, unilateral neglect, and hemiopia.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in aphasia quotient from baseline to week 4;
- Secondary Outcome Measures
Name Time Method Electroencephalo-graph;Severity of Aphasia;Quality of Life;Psychological assessment;Magnetic Resonance Imaging;Change in aphasia quotient from baseline to week 24;Safety index;Disease Prognosis Scale of ischaemic stroke;Degree of nervous functional defects;Cognitive Abilit;Activity of Daily Living;