The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients

Not Applicable

Recruiting

• Conditions: COPD
• Interventions: Diagnostic Test: the changes of end expiratory lung impedence; Diagnostic Test: the changes of end expiratory lung volume

• Registration Number: NCT05585060
• Lead Sponsor: The First Affiliated Hospital of Guangzhou Medical University

Brief Summary

The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping, dynamic pulmonary hyperinflation (DPH), therefore the intrinsic PEEP (PEEPi) increases. It is worthwhile to explore bedside methods to quantify the changes in dynamic pulmonary hyperinflation to guide safe and effective mechanical ventilation in airflow limited patients.

Detailed Description

The study hypothesizes that the electrical impedence tomography (EIT) measured the changes of end expiratory lung impedence (△EELI） could accurately predict the changes of end expiratory lung volume （△EELV） measured by passive expiratory in controlled mechanical ventilated exacerbation COPD patients. The research intended to conduct a research to explore the relationship between △EELI and △EELV induced by external PEEP changes in ventilated exacerbation COPD patients.

Study Timeline

• Study Start: 2022-09-13
• Study First Submitted: 2022-10-15
• Study First Submitted QC: 2022-10-15
• Study First Posted: 2022-10-18
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-19
• Last Update Posted: 2022-11-22
• Primary Completion: 2023-10-08
• Study Completion: 2023-10-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• 2022.7-2023.1 exacerbation COPD invasive ventilated patients admitted to the first affiliated Guangzhou medical university; 35 to 80 years old; in stable condition judged by clinicians

Exclusion Criteria

• SpO2<88%; instable hemodynamic (MAP<65mmHg；Norepinephrine> 0.1ug/kg.min); pregnancy; 4 hour intravenous diuretics use before research; chest deformity and trauma, subpleural pulmonary bulla; implanted electronic devices(cardiac pacemaker, implantable cardioversion defibrillator,ect); tumour or other organ dysfunction; refuse to signature the informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
PEEP titration for mechanical ventilated AECOPD patients	the changes of end expiratory lung impedence	Pre- and post-self-controlled trials for invasive mechanical ventilated AECOPD patients during PEEP titration.
PEEP titration for mechanical ventilated AECOPD patients	the changes of end expiratory lung volume	Pre- and post-self-controlled trials for invasive mechanical ventilated AECOPD patients during PEEP titration.

Primary Outcome Measures

Name	Time	Method
the changes of end expiratory lung volume	10 minutes	measured by EIT and IC maneuver

Secondary Outcome Measures

Name	Time	Method
intrinsic PEEP	10 minutes	measured by Esophageal balloon catheters

Trial Locations

Locations (1)

The First Affiliated Hospital of Guangzhou Medical; 🇨🇳 Guangzhou, Guangdong, China