Paired Acute Invasive/Non-invasive Stimulation Trial
Not Applicable
Completed
- Conditions
- Chronic Pain
- Registration Number
- NCT03954093
- Lead Sponsor
- University of Oxford
- Brief Summary
Chronic pain patients with implanted dorsal root ganglion stimulators will be randomized to receive transcranial direct current stimulation (tDCS) to the motor cortex, magneto-encephalographically (MEG) localized stimulation or sham stimulation to identify therapeutic efficacy of paired central and peripheral neuromodulation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- Patients who are willing and able to give consent to the study.
- Male or Female, aged 18 years or above with diagnoses of chronic pain.
- Treatment includes Spinal Cord Stimulation, Dorsal Root Ganglion stimulation, or peripheral analgesic stimulation.
Exclusion Criteria
- Patients who do not wish to be in the study.
- Patients with metallic intracranial implants.
- Patients with extreme language barrier that cannot understand the purpose of the study despite the use of an interpreter
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Change in pain scores: 21-point pain scale rating Immediately after 30 minutes of transcranial direct current stimulation 21-point pain scale rating
- Secondary Outcome Measures
Name Time Method Changes in EEG recordings Immediately after 30 minutes of transcranial direct current stimulation Changes in electrical fields of the cortex
Changes in Facial Expression Recognition Performance Immediately after 30 minutes of transcranial direct current stimulation An emotional categorisation task to identify anti-depressant effects
Trial Locations
- Locations (1)
John Radcliffe Hospital
🇬🇧Oxford, Oxfordshire, United Kingdom
John Radcliffe Hospital🇬🇧Oxford, Oxfordshire, United Kingdom