Tumor Perfusion and Hypoxia Evaluation and Comparation in 18F-FDG PET/CT
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Correlation of the distribution of FDG between initial-time and balanced-time PET/CT
研究概览
简要总结
Investigators want to use 18F-FDG PET/CT imaging to reflect tumor perfusion and hypoxia.
详细描述
Perfusion and hypoxia were independent prognositic parameters for tumor patients. Developing a method that can evaluate tumor perfusion and hypoxia noninvasively and conveniently was in urgent need. 18F-FDG PET/CT imaging could reflect tumor hypoxia in 60min balanced imaging was proved and accepted. Moreover, FDG could diffuse out of the vasculature and through cell membranes passively and rapidly due to its lipophilicity, its regional uptake at initial times is expected to reflect tumor perfusion. So, investigators want to use 18F-FDG PET/CT imaging to evaluate tumor perfusion and hypoxia simutaniously，in order to guide the clinical diagnosis and treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1.solid tumor proved by pathology(d>3.0cm);
- •2.age>18-year-old;
- •Karnofsky performance status >70;
- •4.sign the informed consent.
排除标准
- •1.There are obvious metal implants near the tumor;
- •2.Can not lie still for 15 minutes.
- •3.Pregnancy.
结局指标
主要结局
Correlation of the distribution of FDG between initial-time and balanced-time PET/CT
时间窗: 2018.1
Initial-time and balanced-time PET/CT imaging were registrated using PET/CT Compare software in GE AW4.6 workstation. FDG distribution was evaluated in each imaging and the correlation was evaluated.
次要结局
- SUVs in initial-time and balanced-time PET/CT(2018.1)
研究者
Yingying Sun
Attending physician， doctor
Harbin Medical University