Tumor Perfusion and Hypoxia Evaluation and Comparation in 18F-FDG PET/CT
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Perfusion and Hypoxia
- Sponsor
- Harbin Medical University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Correlation of the distribution of FDG between initial-time and balanced-time PET/CT
- Last Updated
- 6 years ago
Overview
Brief Summary
Investigators want to use 18F-FDG PET/CT imaging to reflect tumor perfusion and hypoxia.
Detailed Description
Perfusion and hypoxia were independent prognositic parameters for tumor patients. Developing a method that can evaluate tumor perfusion and hypoxia noninvasively and conveniently was in urgent need. 18F-FDG PET/CT imaging could reflect tumor hypoxia in 60min balanced imaging was proved and accepted. Moreover, FDG could diffuse out of the vasculature and through cell membranes passively and rapidly due to its lipophilicity, its regional uptake at initial times is expected to reflect tumor perfusion. So, investigators want to use 18F-FDG PET/CT imaging to evaluate tumor perfusion and hypoxia simutaniously，in order to guide the clinical diagnosis and treatment.
Investigators
Yingying Sun
Attending physician， doctor
Harbin Medical University
Eligibility Criteria
Inclusion Criteria
- •1.solid tumor proved by pathology(d\>3.0cm);
- •2.age\>18-year-old;
- •Karnofsky performance status \>70;
- •4.sign the informed consent.
Exclusion Criteria
- •1.There are obvious metal implants near the tumor;
- •2.Can not lie still for 15 minutes.
- •3.Pregnancy.
Outcomes
Primary Outcomes
Correlation of the distribution of FDG between initial-time and balanced-time PET/CT
Time Frame: 2018.1
Initial-time and balanced-time PET/CT imaging were registrated using PET/CT Compare software in GE AW4.6 workstation. FDG distribution was evaluated in each imaging and the correlation was evaluated.
Secondary Outcomes
- SUVs in initial-time and balanced-time PET/CT(2018.1)