Perfusion and Hypoxia Evaluation in Tumors Using 18F-FDG PET/CT

• Conditions: Perfusion and Hypoxia

• Registration Number: NCT03373994
• Lead Sponsor: Harbin Medical University

Brief Summary

Investigators want to use 18F-FDG PET/CT imaging to reflect tumor perfusion and hypoxia.

Detailed Description

Perfusion and hypoxia were independent prognositic parameters for tumor patients. Developing a method that can evaluate tumor perfusion and hypoxia noninvasively and conveniently was in urgent need. 18F-FDG PET/CT imaging could reflect tumor hypoxia in 60min balanced imaging was proved and accepted. Moreover, FDG could diffuse out of the vasculature and through cell membranes passively and rapidly due to its lipophilicity, its regional uptake at initial times is expected to reflect tumor perfusion. So, investigators want to use 18F-FDG PET/CT imaging to evaluate tumor perfusion and hypoxia simutaniously，in order to guide the clinical diagnosis and treatment.

Study Timeline

• Study Start: 2016-11-01
• Study First Submitted: 2017-12-04
• Study First Submitted QC: 2017-12-11
• Study First Posted: 2017-12-14
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-20
• Last Update Posted: 2020-02-21
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 1.solid tumor proved by pathology(d>3.0cm);
• 2.age>18-year-old;
• 3. Karnofsky performance status >70;
• 4.sign the informed consent.

Exclusion Criteria

• 1.There are obvious metal implants near the tumor;
• 2.Can not lie still for 15 minutes.
• 3.Pregnancy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of the distribution of FDG between initial-time and balanced-time PET/CT	2018.1	Initial-time and balanced-time PET/CT imaging were registrated using PET/CT Compare software in GE AW4.6 workstation. FDG distribution was evaluated in each imaging and the correlation was evaluated.

Secondary Outcome Measures

Name	Time	Method
SUVs in initial-time and balanced-time PET/CT	2018.1	the SUVmax and SUVmean was calculated in well-perfused area and hypoxia area in tumors using PET/CT Render software in GE AW4.6 workstation.

Trial Locations

Locations (1)

Yingying Sun; 🇨🇳 Harbin, Heil, China