Pilot Study of the Effects of Erythritol on Endothelial Function in Patients With Type 2 Diabetes Mellitus
Not Applicable
Completed
- Conditions
- Type 2 Diabetes Mellitus
- Interventions
- Dietary Supplement: Erythritol-containing beverage
- Registration Number
- NCT01609088
- Lead Sponsor
- Boston University
- Brief Summary
The study will determine whether acute and chronic consumption of a beverage containing erythritol will improve endothelial function in patients with type 2 diabetes mellitus.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- Type 2 diabetes mellitus
- Otherwise healthy
Exclusion Criteria
- Pregnant
- BMI>35 kg/m2
- Long acting insulin treatment
- Other major illness, drug abuse
- Treatment with an investigational drug within 12 weeks
- Treatment with dietary or vitamin supplements
- Smoking within 3 months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Erythritol-containing beverage Erythritol-containing beverage -
- Primary Outcome Measures
Name Time Method Brachial artery flow mediated dilation Change from baseline at 28 days
- Secondary Outcome Measures
Name Time Method Brachial artery flow-mediated dilation Change from baseline at 2 hours Reactive hyperemia, carotid femoral pulse wave velocity, fingertip tonometry.
Reactive hyperemia Change from baseline at 2 hours and 28 days Carotid femoral pulse wave velocity Change from baseline at 28 days Fingertip tonometry Change from baseline at 2 hours and 28 days Urine F2 isoprostanes Change from baseline at 28 days C-reactive protein Change from baseline at 28 days
Trial Locations
- Locations (1)
Boston University School of Medicine
🇺🇸Boston, Massachusetts, United States