Liver Embolization Approaches for Tumor Management - Retrospective and Prospective Analysis of the Short-, Medium-, and Long-term Clinical Course of Patients Subjected to Embolization Treatment for Primary and Secondary Liver Neoplasms
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 580
- 试验地点
- 1
- 主要终点
- Progression free survival
研究概览
简要总结
The goal of this evaluate short, medium and long term outcome of the different embolization techniques in patients with primary and secondary hepatic tumors. The main aim is to evaluate progression free survival following embolization in this study population or evaluate residual hepatic volume in cases in which these techniques are used to induce liver regeneration. This study is an observational registry - all patients will follow their normal therapeutic and treatment scheme as per clinical practice, without any additional intervention.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with patients with primary or secondary liver disease not amenable for surgery or ablation
- •patients with primary or secondary liver tumors candidates for major surgery prior to induction of hypertrophy
- •able and willing to sign informed consent
排除标准
- •pregnant women
- •patients with uncorrectable coagulopathy
- •diffuse extrahepatic disease
- •for lobar TACE and TARE - presence of bilodigestive shunt
- •for TARE - >20% hepatopulmonary shunt
结局指标
主要结局
Progression free survival
时间窗: From time of intervention up to 5 years (Long term)
Residual hepatic volume
时间窗: within 40 days of procedure
Treatment Efficacy
次要结局
- Overall survival(From date of procedure until the date of death from any cause, whichever came first, assessed up to 5 years)
研究者
Francesco De Cobelli
Head of Radiology
IRCCS San Raffaele