The role of diaphragm muscle EMG monitoring on respiratory physiology in mechanically ventilated patients with ARDS: a pilot study
- Conditions
- Acute lung injuryPneumonia1002830210038716
- Registration Number
- NL-OMON34914
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
• Intubated, mechanically ventilated adult patients
• Meeting criteria for ARDS:
o Acute decrease in the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen to 300 mmHg or less
o Bilateral pulmonary infiltrates on chest radiography consistent with edema
o No clinical evidence of left atrial hypertension
• Mean arterial blood pressure >65 mmHg (with or w/o vasopressors).
• Pregnancy (due to altered position of the diaphragm)
• Increased intracranial pressure, or clinical suspicion of elevated intracranial pressure (i.e. neurotrauma)
• Contra-indication for naso-gastric feeding tube
• Diagnosed neuro-muscular disorder before ICU admission
• Recent (<12 hours) use of muscle relaxants
• Exclusion from sedation interruption protocol as used in our institution
• Open chest or -abdomen
• Inability to obtain informed consent
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>• Pressure-time product of the diaphragm (measure for work of breathing)<br /><br>• Patient-ventilator asynchrony index</p><br>
- Secondary Outcome Measures
Name Time Method <p>• Transpulmonary pressure (measure for lung stretch)<br /><br>• Transdiaphragmatic presure (measure for diaphragm function)<br /><br>• Oxynation index (arterial oxygen tension / fraction of inspired oxygen)<br /><br>• Respiratory compliance (tidal volume / plateau pressure - toal PEEP)<br /><br>• Dead space ventilation</p><br>