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Clinical Trials/NCT07527871
NCT07527871
Not yet recruiting
Not Applicable

ED-SMART: Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

Purdue University0 sites650 target enrollmentStarted: May 1, 2026Last updated:

Overview

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
650
Primary Endpoint
Self-reported substance use

Overview

Brief Summary

The purpose of this research study is to learn if an emergency department screening and telehealth intervention reduces substance use among individuals receiving emergency department treatment at The Ohio State University Wexner Medical Center.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Adult at least 18 years of age
  • Lower or Moderate Risk score on one or more substance use types on National Institute on Drug Abuse (NIDA)-Modified Alcohol, Smoking, and Substance Use Involvement Test (ASSIST). Participants may also endorse alcohol use in conjunction with substance use as indicated by an Alcohol Use Disorder Identification Test-Concise (AUDIT-C) score of Moderate Risk.

Exclusion Criteria

  • A priori participant request for participation
  • Concurrently enrolled in other study of substance use disorder prevention
  • Prisoner at time of enrollment
  • Known to be pregnant at time of enrollment
  • Past substance use disorder or substance use treatment
  • High risk score for one or more substances on the NIDA-Modified ASSIST or problematic alcohol use alone

Arms & Interventions

ED-SMART intervention

Experimental

The ED-SMART intervention includes: (i) a brief (approximately 15 minutes) counseling session in the emergency department and (ii) five, monthly brief counseling sessions (approximately 15 to 30 minutes) delivered by telehealth. These sessions will focus on creating individualized strategies to help participants reach their alcohol and substance use reduction goals.

Intervention: ED-SMART intervention (Behavioral)

Substance use information

Placebo Comparator

The substance use information condition will receive printed health information covering information about substance use (e.g., definitions, hazards, potential for addiction, injury, and other consequences). Staff will also discuss ways to utilize primary care or establish care with a primary care provider to provide ongoing follow-up.

Intervention: Substance use information (Behavioral)

Outcomes

Primary Outcomes

Self-reported substance use

Time Frame: From baseline to the sixth month follow-up assessment

Self-reported substance use frequency

Secondary Outcomes

  • Self-reported substance use quantity(From baseline to the six month follow-up)
  • Incidence of positive substance use disorder screen(From baseline to the six month follow-up)
  • Toxicology assays for substance use(From baseline to the six month follow-up assessment)
  • Self-reported healthcare utilization(Baseline to the six month follow-up assessment)
  • Fatal and non-fatal overdose(Baseline to the six month follow-up assessment)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

BrownLab

Professor

Purdue University

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