Optimization of Immunomodulators and Their Withdrawal After Achievement of Mucosal Healing in Long-term Maintenance of Quiescent Ulcerative Colitis
- Conditions
- lcerative Colitis
- Registration Number
- JPRN-UMIN000036506
- Lead Sponsor
- Dokkyo Medical University, Department of Gastroenterology.
- Brief Summary
A significantly higher remission maintenance rate was observed in the IM continuation group (p??<??0.01). No significant difference was observed between the IM continuation group with a WBC of less than 3000 or a MCV of 100 or greater and the IM continuation group with a WBC of 3000 or greater and a MCV of 99 or lower (p??=??0.08). Higher remission maintenance rates were observed in the IM continuation group of patients for whom MH had been achieved (p??=??0.03).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 89
Not provided
Of the 283 cases, a case where remission had not been achieved within 1 year of the oral administration of immunomodulators, a case with a history of anti-TNF alfa antibody agent administration, a case with less than 80% adherence to immunomodulators were excluded.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoint was the remission maintenance rate following immunomodulators withdrawal indicated by a Mayo endoscopic subscore of 0.
- Secondary Outcome Measures
Name Time Method