Functional MRI of Hypoxia-mediated Rectal Cancer Aggressiveness
Completed
- Conditions
- Rectal NeoplasmsRectal DiseasesGastrointestinal DiseasesGastrointestinal Neoplasms
- Registration Number
- NCT01816607
- Lead Sponsor
- University Hospital, Akershus
- Brief Summary
The purpose of this study is to establish a reliable method for detection of rectal cancer patients with aggressive tumor at risk of metastatic disease and death by functional MRI.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 192
Inclusion Criteria
- The patient is willing and able to give full written consent according to the protocol approved by the Regional Ethics Committee.
- The patient has confirmed rectal cancer diagnosis and is scheduled to radical surgery alone or preoperative CRT followed by surgery.
- The patient is ≥ 18 years.
- The patient has no prior rectal cancer treatment.
- The patient has adequate renal function: creatinine clearance ≥ 60 ml/minute.
- The patient has signed the written informed consent according to the protocol approved by the Regional Ethics Committee.
Exclusion Criteria
- The patient has contraindication to MRI or MRI contrast agent according to clinical practice.
- The patient wants to withdraw for any reason during the study.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presence of metastatic disease 5 years after rectal cancer treatment five years
- Secondary Outcome Measures
Name Time Method Histomorphological response to preoperative chemoradiotherapy 8 weeks
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie hypoxia-driven aggressiveness in rectal cancer as studied in NCT01816607?
How do new functional MRI protocols in NCT01816607 compare to standard-of-care imaging for rectal cancer prognosis?
Which biomarkers correlate with hypoxia-mediated tumor aggressiveness in rectal cancer patients using functional MRI?
What adverse events are associated with hypoxia-targeted functional MRI techniques in gastrointestinal neoplasms?
Are there combination approaches involving functional MRI and hypoxia-targeting therapies for rectal cancer?
Trial Locations
- Locations (1)
Akershus University Hospital
🇳🇴Lørenskog, Akershus, Norway
Akershus University Hospital🇳🇴Lørenskog, Akershus, Norway