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Functional MRI of Hypoxia-mediated Rectal Cancer Aggressiveness

Completed
Conditions
Rectal Neoplasms
Rectal Diseases
Gastrointestinal Diseases
Gastrointestinal Neoplasms
Registration Number
NCT01816607
Lead Sponsor
University Hospital, Akershus
Brief Summary

The purpose of this study is to establish a reliable method for detection of rectal cancer patients with aggressive tumor at risk of metastatic disease and death by functional MRI.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
192
Inclusion Criteria
  • The patient is willing and able to give full written consent according to the protocol approved by the Regional Ethics Committee.
  • The patient has confirmed rectal cancer diagnosis and is scheduled to radical surgery alone or preoperative CRT followed by surgery.
  • The patient is ≥ 18 years.
  • The patient has no prior rectal cancer treatment.
  • The patient has adequate renal function: creatinine clearance ≥ 60 ml/minute.
  • The patient has signed the written informed consent according to the protocol approved by the Regional Ethics Committee.
Exclusion Criteria
  • The patient has contraindication to MRI or MRI contrast agent according to clinical practice.
  • The patient wants to withdraw for any reason during the study.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Presence of metastatic disease 5 years after rectal cancer treatmentfive years
Secondary Outcome Measures
NameTimeMethod
Histomorphological response to preoperative chemoradiotherapy8 weeks

Trial Locations

Locations (1)

Akershus University Hospital

🇳🇴

Lørenskog, Akershus, Norway

Akershus University Hospital
🇳🇴Lørenskog, Akershus, Norway

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