An open label study with objective sleepregistration on the effects of Doxazosin as treatment for PTSD, especially for sleep disturbance - Doxazosin for PTSD With sleepregistration (DoPS).

Parnassia Bavo Groep (Den Haag)0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•- Good speaking and writing in Dutch
•- PDS above 18
•- CAPS recurrent distressing dreams item score above 5
•- CAPS difficulty falling or staying asleep item above 5
•- No medication except contraceptives or analgetics like paracetamol
•- No alcohol more than two consumptions a day
•- Medication use of psychotropics has stopped at least one month before entrance of the study
•- If psychotherapy has not been started yet it will not be initiated during the trial; If started it will be paused for the period of the study. Medication with influence on sleep-EEG will not be started during the study period (paracetamol and contraceptives are allowed).

•Psychiatric:
•- Lifetime schizophrenia,
•- schizoaffective disorder,
•- bipolar disorder,
•- severe depressive disorder (MADRS > 34) (for screening: QIDS > 15)
•- cognitive disorder,
•- current delirium,
•- substance use within 2 months of the study; alcohol is allowed if not more than 2 consumptions a day.
•- severe psychiatric instability (including evidence of being actively suicidal or homicidal).
•- any behavior which poses an immediate danger to patient or others.;Somatic:
•- preexisting hypotension or (anamnestic) orthostatic hypotension
•- hypertension unless stable with help of anti-hypertensive medication.
•- Known for severe ischaemic heart disease
•- disease with strong reduced functioning of the liver.
•- Women of childbearing potential with either positive pregnancy test or refusal to use effective birth control method.
•- Allergy or previous adverse reaction to doxazosin or other alpha-1 antagonist.
•- Hypersensitivity to quinazolinderivates
•- Known for hypertrophy of the prostate without treatment.
•- Gastro-intestinal obstruction
•- oesophageal obstruction
•- overflow bladder or anuria with or without progressive renal insufficiency

发起方

Parnassia Bavo Groep (Den Haag)